[S13] neo-PTMs: Chemistry and Biology of Hitherto Unknown Biotic/Abiotic Modifications

Sun. Mar 26, 2023 1:50 PM - 3:50 PM [Room B1] Institute for the Advancement of Higher Education: N1 (Bldg. N: 1F)

Organizer: Kenzo Yamatsugu

Life emerges from biomolecules and their intervening chemical networks. For example, the human genome only encodes the primary sequences of 20,000 to 25,000 proteins, but their transcription products, RNA, undergo various splicing and chemical modifications to form approximately 100,000 transcriptomes. Furthermore, the translation products undergo various post-translational modifications (PTMs) to form more than one million proteomes. In other words, it has become clear that life is driven by a greater variety of chemical modifications than previously thought. Furthermore, the molecular structures and functions that chemistry can construct are limitless, and there is no reason why the chemical modifications of biomolecules need to be limited to those that are inherently found. In this symposium, we will define these "chemical modifications that are not originally possessed by living organisms or whose existence is hitherto unknown" as neo-PTMs. We discuss chemical/biological technologies and advancements to find, understand, introduce, and manipulate the neo-PTMs.

+Add all to schedule

はじめに：山次健三（東大院薬） (1:50 PM - 1:54 PM)

1:54 PM - 2:12 PM

[S13-01] A chemical catalyst enabling histone acylation with endogenous acyl-CoA

○Kenzo Yamatsugu¹ (1. Grad. Sch. Pharm. Sci. Univ. Tokyo)

2:12 PM - 2:30 PM

[S13-02] Artificial chemical modification to identify substrate of protein methyltransferases

○Yoshihiro Sohtome^1,2 (1. RIKEN CPR, 2. RIKEN CSRS)

2:30 PM - 2:48 PM

[S13-03] Discovery and biological role of protein histidine methyltransferases using a neo-PTMs probe

○Tadahiro Shimazu¹ (1. RIKEN CPR)

2:48 PM - 3:17 PM

[S13-04] Discovery of reversible RNA phosphorylation and its function
-exploring, characterizing, and manipulating RNA modifications-

○Takayuki Ohira¹ (1. Grad. Sch. of Eng., Univ. of Tokyo.)

3:17 PM - 3:46 PM

[S13-05] Pathogenic mechanism of intellectual disability caused by the loss of a tRNA methylase FTSJ1

○Takeshi Chujo¹ (1. Faculty Life Sci. Kumamoto Univ.)

おわりに：五月女宜裕（理研CPR） (3:46 PM - 3:50 PM)