[MS11-4C-2] The efficiency of Ketogenic diet on Dravet syndrome
[Objective]: To study the efficiencyof ketogenic diet on seizure control, improvement of cognitive impairment and ataxia in Dravet syndrome patients by comparing it with anti-epileptic drugs.
[Methods]: We studied 42 patients diagnosed with Dravet syndrome via genetic test in Xiangya Hospital from 2010-2016. Information were collected retrospectively, including demographic characteristics, seizure frequency, movement and cognitive impairment and ataxia. Clinical conclusion and analysis was made based on responses to anti-epileptic drugs and ketogenic diet.
[Result]: Before the genetic test, all the 42 patients were treated with 1-5 anti-epileptic drugs. Only 7% of the patients showed seizure free, 12% showed remarkable effect, another 12% showed effective, 45% responded invalid and 23.8% had increased seizure frequency. After confirming with genetic test, we corrected therapy by stopping using sodium channel blockers and adding ketogenic diet to 17 patients, results were as follow: 19% showed seizure free, 14.3% showed remarkable effect, 11% showed effective, 38% responded invalid, only 2% had increased seizure frequency. Among 17 patients treated with ketogenic diet and AEDs, 23% showed seizure free at least for 6 months，37.5% showed devlopmental improvement after ketogenic diet, 11.7% had improved ataxia.
[Conclusions]: Ketogenic diet has positive impacts on Dravet syndrome, it can reduce the seizure frequency especially status epilepsy, it can also improve mental development and ataxia, moreover no side effects was detected in our patients, therefore ketogenic diet can be a therapeutic method for Dravet syndrome.
[Methods]: We studied 42 patients diagnosed with Dravet syndrome via genetic test in Xiangya Hospital from 2010-2016. Information were collected retrospectively, including demographic characteristics, seizure frequency, movement and cognitive impairment and ataxia. Clinical conclusion and analysis was made based on responses to anti-epileptic drugs and ketogenic diet.
[Result]: Before the genetic test, all the 42 patients were treated with 1-5 anti-epileptic drugs. Only 7% of the patients showed seizure free, 12% showed remarkable effect, another 12% showed effective, 45% responded invalid and 23.8% had increased seizure frequency. After confirming with genetic test, we corrected therapy by stopping using sodium channel blockers and adding ketogenic diet to 17 patients, results were as follow: 19% showed seizure free, 14.3% showed remarkable effect, 11% showed effective, 38% responded invalid, only 2% had increased seizure frequency. Among 17 patients treated with ketogenic diet and AEDs, 23% showed seizure free at least for 6 months，37.5% showed devlopmental improvement after ketogenic diet, 11.7% had improved ataxia.
[Conclusions]: Ketogenic diet has positive impacts on Dravet syndrome, it can reduce the seizure frequency especially status epilepsy, it can also improve mental development and ataxia, moreover no side effects was detected in our patients, therefore ketogenic diet can be a therapeutic method for Dravet syndrome.