[MS7-3C-4] Long Term Cognitive Outcome in Preterm Infants With Mild Periventricular Echo-enhance
Periventricular echo-enhance (PVE) is a common phenomenon in the first two weeks of preterm infants. The long term prognosis of the mild PVE has not been thoroughly investigated. In this study, 64 preterm infants were enrolled and divided into four cohorts judged by transcranial ultrasound examination, including A cohort with normal scans (n=26), B with mild intravascular hemolysis (IVH, n=23), C with mild PVE (n=1), D with both mild IVH and mild PVE (n=14). Combined Raven Test and Peabody Picture Vocabulary Test were assessed before they entered a primary school at six years old. C cohort is too small and not in our further analysis. The gestational age, birth weight, gender and average hospitalized duration in the three cohorts has no significant difference. The average age of cohort A, B and D in our follow-up assessment were 6.46±0.30, 6.47±0.23, 6.21±0.16 respectively. The average scores of Combined Raven test in A, B and D cohorts are 113.3± 15.1,112.3± 15.0,117.6± 12.9 respectively, with no statistical difference（P=0.56）. The average scores of Peabody Picture Vocabulary Test are 119.9± 16.0,118.9± 16.3,111.6± 17.1 respectively, with no statistical difference（P=0.36）. The percentage of abnormal vision in A, B and D were 19%,39%,50% respectively, with a statistically significant difference（P=0.037）.Our study showed that mild periventricular echo-enhance in preterm newborns is usually have a good cognitive outcome. But mild IVH and PVE in preterm increased later vision problems.