[MS8-3D-3] Risk Factors of Epilepsy Onset in Infancy: Case Control Study
[Background] Epilepsy is the most common cause of morbidity in pediatric neurology, which results in delayed developmental problems and decreased quality of life during infancy. Risk factors of epilepsy in infancy such as hereditary, prenatal, perinatal and postnatal should be detected to be able to find the predictors of the incidence and to promptly manage epilepsy.
[Aim] (1) To identify the risk factors of epilepsy in infants. (2) To find the probability of epilepsy based on the predictor score of risk factors.
[Method] A case control study for patients diagnosed with epilepsy during infancy who comes to Neurology outpatient clinic Department of Child Health, Faculty of Medicine, University of Indonesia from January 2011 to December 2015. Data was collected from medical records and parent interviews. The risk factors that are considered important are then analyzed multivariately.
[Result] The incidence of epilepsy in infant from 2011-2015 is 167 patients. In the multivariate analysis, the significant risk factors are family history with epilepsy (p<0.001 and OR 9.10; 95%; CI 2.00-41.34), microcephaly (p<0.001 and OR 20.78; 95% CI 6.04-71.75), febrile seizure (p<0.001 and OR 13.41; 95% CI 3.86-46.64), no exclusive breastfeeding (p<0.001 and OR 9.68; 95% CI 4.61-20.28) and delayed development (p<0.001 and OR 16.04; 95% CI 6.20-41.48). The probability of epilepsy in infants with more than 1 risk factor is 39%, with 2 risk factors is 86%.
[Conclusion] The significant risk factors are family history with epilepsy, microcephaly, febrile seizure, delayed development and no exclusive breastfeeding.
[Aim] (1) To identify the risk factors of epilepsy in infants. (2) To find the probability of epilepsy based on the predictor score of risk factors.
[Method] A case control study for patients diagnosed with epilepsy during infancy who comes to Neurology outpatient clinic Department of Child Health, Faculty of Medicine, University of Indonesia from January 2011 to December 2015. Data was collected from medical records and parent interviews. The risk factors that are considered important are then analyzed multivariately.
[Result] The incidence of epilepsy in infant from 2011-2015 is 167 patients. In the multivariate analysis, the significant risk factors are family history with epilepsy (p<0.001 and OR 9.10; 95%; CI 2.00-41.34), microcephaly (p<0.001 and OR 20.78; 95% CI 6.04-71.75), febrile seizure (p<0.001 and OR 13.41; 95% CI 3.86-46.64), no exclusive breastfeeding (p<0.001 and OR 9.68; 95% CI 4.61-20.28) and delayed development (p<0.001 and OR 16.04; 95% CI 6.20-41.48). The probability of epilepsy in infants with more than 1 risk factor is 39%, with 2 risk factors is 86%.
[Conclusion] The significant risk factors are family history with epilepsy, microcephaly, febrile seizure, delayed development and no exclusive breastfeeding.