[P1-109] Anti-N-methyl-D-aspartate Receptor Encephalitis with Severe Autonomic Dysfunctions in a Male Toddler: A Case Report
Objective: To present the manifestations of anti-N-methyl-D-aspartate receptor encephalitis in a three-year-old patient with severe autonomic dysfunctions. Methodology: A combination of clinical characterization and follow-up examination, electroencephalogram (EEG), and laboratory investigations. Results: We report the case of a previously healthy three-year-old boy with a two-month history of progressive mental status changes, abnormal movements, and severe autonomic dysfunctions, including dysphagia, constipation, and rapid weight loss. The serum and CSF tests for the anti-NMDA receptor antibodies were positive. Results of EEG showed “extreme delta brush.” After administration of first-line immunomodulatory treatments, the boy almost recovered after a six-month follow-up assessment. Conclusions: The severe widespread autonomic dysfunction, especially gastrointestinal dysmotility and anhidrosis, can manifest in patients with anti-NMDA receptor encephalitis.