[P1-140] Increased levels of anti-phosphatidylcholine and anti-phosphatidylethanolamine antibodies in three pediatric patients with cerebral infarction
【Background】Cerebral infarction in children is rare and often occurs secondary to moyamoya disease, hereditary coagulopathies, vasculitis, antiphospholipid antibody syndrome, heart disease, mitochondrial disease. However, in some cases, the causes of cerebral infarction is unknown. We have previously reported a central retinal vein occlusion in a pediatric patient with systemic lupus erythematosus and anti-phosphatidylcholine (PC) anti-phosphatidylethanolamine (PE) antibodies without anti-cardiolipin (CL) antibody.
【Objective】To elucidate serum levels of these antiphospholipid antibodies in patients with cerebral infarction.
【Patients and methods】We examined the serum levels of IgG antibodies for CL, PC, PE and phosphatidylserine (PS) using the serum obtained twice every 12 weeks from these three patients with cerebral infarction whose primary disorders are unknown by routine examination.
【Results】There were no patients in which anti-CL and anti-PS antibodies levels was increased in both paired serum samples. However, a continuous increase in anti-PC and anti-PE antibodies levels were detected. For the five disease control patients of cerebral infarction due to other primary disorders such as protein C deficiency, there was no such increase in these antibodies levels.
【Conclusions】PC and PE are a major component of the phospholipids of vascular endothelial cells, while CL is a minor component. Anti-PC and anti-PE antibodies, as well as anti-CL antibody, might also be risk factors with cerebral infarction.
【Objective】To elucidate serum levels of these antiphospholipid antibodies in patients with cerebral infarction.
【Patients and methods】We examined the serum levels of IgG antibodies for CL, PC, PE and phosphatidylserine (PS) using the serum obtained twice every 12 weeks from these three patients with cerebral infarction whose primary disorders are unknown by routine examination.
【Results】There were no patients in which anti-CL and anti-PS antibodies levels was increased in both paired serum samples. However, a continuous increase in anti-PC and anti-PE antibodies levels were detected. For the five disease control patients of cerebral infarction due to other primary disorders such as protein C deficiency, there was no such increase in these antibodies levels.
【Conclusions】PC and PE are a major component of the phospholipids of vascular endothelial cells, while CL is a minor component. Anti-PC and anti-PE antibodies, as well as anti-CL antibody, might also be risk factors with cerebral infarction.