[P1-24] An Infant with Febrile Infection-Related Epilepsy Syndrome
[Introduction] Infant with febrile infection- related epilepsy syndrome (FIRES) occurred mostly in school-aged children, but could it affect younger children?
[Methodology] Analyse one child’s clinical manifestations, imaging findings, laboratory examinations, treatment and disease evolution which support the diagnosis of FIRES.
[Results] A 13 months old boy complained by “fever for 11 days, recurrent seizures for 8 days” was hospitalized. In the course of hospitalization, he suffered from refractory seizures similar to acute encephalitis. The pathogen was not found in cerebrospinal fluid and serum or other body fluids, autoimmune encephalitis antibody was negative. The fever lasted eighteen days. He had been treated with phenobarbital, midazolam, sodium valproate, carbamazepine, levetiracetam, acyclovir and immunoglobulin, but there was still a seizure, accompanied by irritability or lethargy. He resisted to 2 or more antiepileptic drugs, and the frequency of onset was over 1 time per month. His cognitive function was severely impaired, which met the diagnostic criteria of FIRES made by Howell in 2012.There is no causitive gene mutations by WES.
[Conclusions] This case is characterized by a small age of onset and long duration of fever which are different from most of the FIRES cases reported in the past.
[Methodology] Analyse one child’s clinical manifestations, imaging findings, laboratory examinations, treatment and disease evolution which support the diagnosis of FIRES.
[Results] A 13 months old boy complained by “fever for 11 days, recurrent seizures for 8 days” was hospitalized. In the course of hospitalization, he suffered from refractory seizures similar to acute encephalitis. The pathogen was not found in cerebrospinal fluid and serum or other body fluids, autoimmune encephalitis antibody was negative. The fever lasted eighteen days. He had been treated with phenobarbital, midazolam, sodium valproate, carbamazepine, levetiracetam, acyclovir and immunoglobulin, but there was still a seizure, accompanied by irritability or lethargy. He resisted to 2 or more antiepileptic drugs, and the frequency of onset was over 1 time per month. His cognitive function was severely impaired, which met the diagnostic criteria of FIRES made by Howell in 2012.There is no causitive gene mutations by WES.
[Conclusions] This case is characterized by a small age of onset and long duration of fever which are different from most of the FIRES cases reported in the past.