[P1-36] PDS Scale can alert the occurrence of Posterior reversible encephalopathy syndrome
[Introduction] To establish a Posterior reversible encephalopathy syndrome diagnosis score scale (PDS Scale) for early diagnosis and intervention.
[Method] 31 patients diagnosed with PRES in 5 medical centers from January 1, 2001 to April 1, 2013 were recruited. Their clinical data and characteristics of the electroencephalogram (EEG) were recorded in a standardized way and analyzed retrospectively. The scale was prospectively used to evaluate and monitor chemotherapy in children with acute lymphoblastic leukemia, and early intervention was performed on children who might have PRES.
[Results] Seizures were the most common clinical features of PRES in 29 patients (93.5%). Imaging findings showed that the lesions were mostly bilateral, mainly involving the parietal and occipital lobes. Children with hematological malignancies had a poorer prognosis. All patients’ EEG showed slow wave, 52.9% with δ activity and θ activity simultaneously. According to the retrospective analysis of PRES and non-PRES children, PDS scale showed the sensitivity of 0.97, the specificity of 0.87, the positive predictive value of 0.89, and the negative predictive value of 0.93. 57 patients with acute lymphoblastic leukemia were prospectively monitored on risk factors and EEG. When the score was 10 points or more, PRES was highly suspected. Prophylactic intervention can prevent the occurrence of PRES.
[Conclusions] Seizures are the most common clinical features in children with PRES. Slow wave in background activity is a common EEG manifestation of PRES. When the score is 10 or more, PRES is highly suspected. Prophylactic intervention can prevent the occurrence of PRES.
[Method] 31 patients diagnosed with PRES in 5 medical centers from January 1, 2001 to April 1, 2013 were recruited. Their clinical data and characteristics of the electroencephalogram (EEG) were recorded in a standardized way and analyzed retrospectively. The scale was prospectively used to evaluate and monitor chemotherapy in children with acute lymphoblastic leukemia, and early intervention was performed on children who might have PRES.
[Results] Seizures were the most common clinical features of PRES in 29 patients (93.5%). Imaging findings showed that the lesions were mostly bilateral, mainly involving the parietal and occipital lobes. Children with hematological malignancies had a poorer prognosis. All patients’ EEG showed slow wave, 52.9% with δ activity and θ activity simultaneously. According to the retrospective analysis of PRES and non-PRES children, PDS scale showed the sensitivity of 0.97, the specificity of 0.87, the positive predictive value of 0.89, and the negative predictive value of 0.93. 57 patients with acute lymphoblastic leukemia were prospectively monitored on risk factors and EEG. When the score was 10 points or more, PRES was highly suspected. Prophylactic intervention can prevent the occurrence of PRES.
[Conclusions] Seizures are the most common clinical features in children with PRES. Slow wave in background activity is a common EEG manifestation of PRES. When the score is 10 or more, PRES is highly suspected. Prophylactic intervention can prevent the occurrence of PRES.