[P1-44] Status Epilepticus Manifested as Continuous Epileptic Spasms
Introduction: There have been rare reports of continuous epileptic spasms in the literature. Methods: This study was a retrospective design to review the medical charts of 11 cases manifesting continuous epileptic spasms lasting more than 30 minutes. Results: one case were admitted in 2011 and 10 between 2014 to 2016. Aetiologies were acute symptomatic in 6, including encephalitis and encephalopathy, and remote symptomatic in 5, including cerebral cortical malformation, de novo KCNQ2 mutation, chromosomal aberration and electroclinical epilepsy syndrome of unknown aetiology. The continuous epileptic spasms were characterized by their (1) long-duration (frequently lasting days, up to months); (2) prominently and frequently observed upon arousal from sleep; (3) attenuation or cessation with sleep. The interictal electroencephalograms showed hypsarrhythmia or its variants, including burst-suppression. Follow-up period was more than 12 months on average. The spasms were refractory to immune adjustment therapies, ketogenic diet therapy. Most patients had significant neurologic sequela. Conclusion: Continuous epileptic spasms as a form of status epilepticus can result from severe specific brain impairments. Its diagnosis is challenging and its treatment is resistant to current available therapies.