[P1-63] Risk Factors for Frontal Lobe Dysfunctions in Children with Frontal Lobe Epilepsy
[Introduction] This analysis focuses on the risk for frontal lobe dysfunctions after seizure onset in children with nonlesional frontal lobe epilepsy (FLE).
[Methodology] Eligible candidates were children between 6 and 15 years old. Scores of the attention deficit/hyperactivity disorder (ADHD)-rating scale (ADHD-RS) and Wisconsin card sorting test (WCST) obtained at seizure onset at baseline. Behavioral and cognitive changes were evaluated using the ADHD-RS and perseverative errors of Nelson (PEN) at 6, 12, and 24 months after seizure onset. The relationship between seizure activity or other clinical manifestations and neuropsychological disturbances was analyzed.
[Results] In 34 patients with FLE, the ADHD-RS score at 24 months after onset was most strongly influenced by the presence of status epileptics (SE) (p=0.004; β=0.490), followed by seizure frequency (p=0.021; β=0.382). In addition, the increase of ADHD-RS was most strongly influenced by seizure frequency (p=0.000; β=0.635), followed by presence of SE (p=0.005; β=0.402). In contrast, the score of PEN on WCST at 24 months was most strongly influenced by seizure frequency (p=0.001; β=0.724), followed by age at onset (p=0.030; β=-0.250). In addition, the increase of PEN on WCST was most strongly influenced by seizure frequency (p=0.001; β=0.872), followed by right-lateralization of epileptic foci (p=0.033; β=0.216). A significant correlation was also identified between the increase of scores of ADHD-RS and PEN on WCST at 24 months (r=0.880, p<0.001). The only clinical factor associated with both behavioral and cognitive problems was seizure frequency.
[Conclusion] Seizure frequency may be related to neuropsychological outcome including behavioral problems.
[Methodology] Eligible candidates were children between 6 and 15 years old. Scores of the attention deficit/hyperactivity disorder (ADHD)-rating scale (ADHD-RS) and Wisconsin card sorting test (WCST) obtained at seizure onset at baseline. Behavioral and cognitive changes were evaluated using the ADHD-RS and perseverative errors of Nelson (PEN) at 6, 12, and 24 months after seizure onset. The relationship between seizure activity or other clinical manifestations and neuropsychological disturbances was analyzed.
[Results] In 34 patients with FLE, the ADHD-RS score at 24 months after onset was most strongly influenced by the presence of status epileptics (SE) (p=0.004; β=0.490), followed by seizure frequency (p=0.021; β=0.382). In addition, the increase of ADHD-RS was most strongly influenced by seizure frequency (p=0.000; β=0.635), followed by presence of SE (p=0.005; β=0.402). In contrast, the score of PEN on WCST at 24 months was most strongly influenced by seizure frequency (p=0.001; β=0.724), followed by age at onset (p=0.030; β=-0.250). In addition, the increase of PEN on WCST was most strongly influenced by seizure frequency (p=0.001; β=0.872), followed by right-lateralization of epileptic foci (p=0.033; β=0.216). A significant correlation was also identified between the increase of scores of ADHD-RS and PEN on WCST at 24 months (r=0.880, p<0.001). The only clinical factor associated with both behavioral and cognitive problems was seizure frequency.
[Conclusion] Seizure frequency may be related to neuropsychological outcome including behavioral problems.