[P1-66] Cognitive Impairment in Idiopathic or Cryptogenic Epilepsy: Characterization and Risk Factors Analysis
[ Introduction ]
Cognitive impairment has been recognized as a severe comorbidity or sequel to epilepsy, which may do more harm than the epilepsy itself. This study was conducted to evaluate the cognitive impairment of patients with idiopathic or cryptogenic epilepsy and to research the influencing factors on cognitive function.
[ Methodology ]
we recruited 35 patients with idiopathic or cryptogenic epilepsy together with 39 healthy volunteers. Cognitive tests and clinical characteristics of the patients were analysed. The potential relation between the cognitive impairment and the risk factors were also studied.
[ Results ]
Patients with idiopathic or cryptogenic epilepsy scored worse than the healthy volunteers in most cognitive subtests, and the IQ-scores were also below the average. We conducted that patients with secondarily generalized tonic-clonic seizure got the lowest score ( p<0.01 ). Duration of epilepsy was also an important factor that affected cognitive function. Among the patients who had FIQ between 80 and 89, the ratio of patients with long duration was much higher than that with short duration ( p<0.05 ). For the effect of discharged location on cognition, verbal cognition was related to temporal lobe abnormalities and performance cognition was related to frontal lobe abnormalities.
[ Conclusions ]
Our study shows that cognitive impairment is common among patients with idiopathic or cryptogenic epilepsy. It influences patients widely, especially on their attention, memory, and visual motion. The type of seizure, duration of epilepsy, and discharged location affect the cognitive function at some extent.
Cognitive impairment has been recognized as a severe comorbidity or sequel to epilepsy, which may do more harm than the epilepsy itself. This study was conducted to evaluate the cognitive impairment of patients with idiopathic or cryptogenic epilepsy and to research the influencing factors on cognitive function.
[ Methodology ]
we recruited 35 patients with idiopathic or cryptogenic epilepsy together with 39 healthy volunteers. Cognitive tests and clinical characteristics of the patients were analysed. The potential relation between the cognitive impairment and the risk factors were also studied.
[ Results ]
Patients with idiopathic or cryptogenic epilepsy scored worse than the healthy volunteers in most cognitive subtests, and the IQ-scores were also below the average. We conducted that patients with secondarily generalized tonic-clonic seizure got the lowest score ( p<0.01 ). Duration of epilepsy was also an important factor that affected cognitive function. Among the patients who had FIQ between 80 and 89, the ratio of patients with long duration was much higher than that with short duration ( p<0.05 ). For the effect of discharged location on cognition, verbal cognition was related to temporal lobe abnormalities and performance cognition was related to frontal lobe abnormalities.
[ Conclusions ]
Our study shows that cognitive impairment is common among patients with idiopathic or cryptogenic epilepsy. It influences patients widely, especially on their attention, memory, and visual motion. The type of seizure, duration of epilepsy, and discharged location affect the cognitive function at some extent.