[P1-70] Epileptic seizure, as the first symptom of hypoparathyroidism in children, does not require anti-epileptic drugs
Patients with hypoparathyroidism exhibit metabolic disorders (hypocalcemia) and structural abnormalities in the brain (brain calcifications). The need for antiepileptic drug (AED) treatment for epileptic seizures in children with hypoparathyroidism has been determined. This study aimed to evaluate the data of two medical centers in Beijing based on the diagnosis of epileptic seizure, as the first symptom of hypoparathyroidism in children. A total of 42 patients were included and assigned to the AED and non-AED treatment groups in a 1:2 matched case-control study. Results showed that the seizure outcome after one year of AED treatment was not significantly different from the controls. The subgroup analysis of patients with subcortical calcifications revealed that the seizure outcome was still not significantly different between the treatment and control groups. Therefore, AED treatment cannot improve the seizure outcomes in children with parathyroid disorder, even in cases where the suspected structural seizure was caused by subcortical calcifications. Clinicians must adequately consider the use of AEDs in these patients. Epileptic seizure as the first symptom of hypoparathyroidism in children does not require antiepileptic drugs