[P1-85] Seizure characteristics with mild gastroenteritis caused by norovirus infection.
[Background]
Seizures with or without fever can be associated with noroviral infection as the feature of benign convulsion with mild gastroenteritis(CwG). Here we retrospectively analyzed clinical features in pediatric population who presented seizures with confirmed noroviral infection.
[Patients and methods]
Medical records of pediatric patients under 15 year-old were reviewed who had admitted with seizure with gastroenteritis between July, 2014 and June, 2016 in department of pediatrics in Myongji Hospital. Specific diagnosis of each viral agents from stool sample was made by multiplex reverse transcription polymerase chain reaction(PCR) assays including norovius genogroup I and II.
[Results]
Total 48 patients (25 males and 23 females) were included in this study. Mean age (± SD) was 30.8±26.8 months (2~132 months). Among 48 eligible patients, 21 have noroviral genogroup II and other 27 have non-noroviral induced gastroenteritis. Eight patients(38.1%) in NGE presented seizures with fever and 13 patients(48.1%) in NNGE. Mean frequency of seizures were 1.81±1.06 times in NGE and 1.85±1.38 in NNGE. All patients presented generalized tonic or tonic clonic seizures and 2 patients (9.5%) presented status epilepticus.
[conclusions]
Seizures with noroviral induced gastroenteritis seem to present with generalized seizures. Fever was less commonly reported in noroviral gastroenteritis than non-noroviral gastroenteritis. About 10% of patients reported status epilepticus as the first presentation in both groups, more cautious observations are required. Larger scaled observation is further required for detailed correlation in norovirus and non-norovirus groups.
Seizures with or without fever can be associated with noroviral infection as the feature of benign convulsion with mild gastroenteritis(CwG). Here we retrospectively analyzed clinical features in pediatric population who presented seizures with confirmed noroviral infection.
[Patients and methods]
Medical records of pediatric patients under 15 year-old were reviewed who had admitted with seizure with gastroenteritis between July, 2014 and June, 2016 in department of pediatrics in Myongji Hospital. Specific diagnosis of each viral agents from stool sample was made by multiplex reverse transcription polymerase chain reaction(PCR) assays including norovius genogroup I and II.
[Results]
Total 48 patients (25 males and 23 females) were included in this study. Mean age (± SD) was 30.8±26.8 months (2~132 months). Among 48 eligible patients, 21 have noroviral genogroup II and other 27 have non-noroviral induced gastroenteritis. Eight patients(38.1%) in NGE presented seizures with fever and 13 patients(48.1%) in NNGE. Mean frequency of seizures were 1.81±1.06 times in NGE and 1.85±1.38 in NNGE. All patients presented generalized tonic or tonic clonic seizures and 2 patients (9.5%) presented status epilepticus.
[conclusions]
Seizures with noroviral induced gastroenteritis seem to present with generalized seizures. Fever was less commonly reported in noroviral gastroenteritis than non-noroviral gastroenteritis. About 10% of patients reported status epilepticus as the first presentation in both groups, more cautious observations are required. Larger scaled observation is further required for detailed correlation in norovirus and non-norovirus groups.