[P1-92] Trend of subsequent epilepsy in children with recurrent febrile seizures
The trend of epilepsy in children with febrile seizure (FS) was correlated in a retrospective study. In this study, we obtained relevant data from a nationwide cohort database to investigate the trends of subsequent epilepsy in children with recurrent FS history. We identified 10,210 children with FS as the case cohort. The diagnosis date was used as the index date. Controls were matched randomly with each case based on age, sex, urbanization level, parents’ occupation, and index date. We applied the Cox proportional hazard regression to estimate the hazard ratio and confidence interval of FS-associated epilepsy. In this retrospective cohort study, 7,729 FS children and 30,916 controls were selected. The incidence of epilepsy was 11.4-fold higher in the FS cohort than in the controls (5.67 vs. 0.49 per 1000 person-years. The epilepsy incidence rates were 0.49, 4.48, 11.47, and 18.91 per 1000 person-years in controls and the FS children with 1, 2, and ≧3 admissions for FS. In conclusion, FS may increase the risk of subsequent epilepsy occurrence in children. Recurrent FS increased the cumulative incidence of epilepsy.