[P2-105] Surgical Treatment for Structural Infantile Spasms under 6 Months Old: 2 Cases Report
Infantile spasms (IS) is the most common childhood epilepsy encephalopathy. Focal cortical dysplasia (FCD) and gray matter heterotopias (GH) are common structural cause of IS, according to the ILAE guidelines, the first-line treatment is recommended to surgical intervention. However, there is no consensus about how to choose the most suitable operation time, the tolerability and side effects to the operation. Here, we present 2 IS cases, one is FCD, the other is GH. Both the 2 patients were appeared recurrent seizures when they were 2 months old, with poor response to kinds of AEDs, mental and motor development retardation. Seizure types included focal seizures and spasms. Brain MRI of the patients showed abnormal gray signal or suspicious FCD lesions what coincided with the origin of the focal seizures. The patients were performed neuro-surgical treatment when they less than 6 months. Follow-up demonstrated that seizures of both patients were controlled totally several days after the surgery, all the AEDs were reduced gradually in 1 year, and the mental and motor development turned to normal nearly. These 2 IS patients are the youngest cases reported in China who received neuro-surgical treatment with FCD or GH, achieved seizure-free soon after the surgery, without obvious disturbance limb movement disorder after rehabilitation. So, we recommend that IS patients with FCD or GH should be turned to surgical intervention as soon as possible if regular AEDs invalid, what can effectively control seizures, and help to improve intelligence and motor development.
This work was supported by grants from the National Natural Science Foundation of China (No. 81671297).
This work was supported by grants from the National Natural Science Foundation of China (No. 81671297).