[P2-107] Long-term outcome after corpus callosotomy in children with intractable epilepsy
[Introduction] Callosotomy has been considered as a palliative therapy for refractory epilepsy patients with non-focal onset seizures. The aim of this study is to evaluate the long-term effectiveness and safety of corpus callosotomy in children with intractable epilepsy.
[Methodology] A retrospective study evaluated the effectiveness of corpus callosotomy in children with refractory epilepsy. Data collection forms were designed for retrospectively gathering data on each patient’s pre-surgery history, seizures, surgeries, and adverse events.
[Results] We describe 37 children (21 males and 16 females; mean age at surgery: 10.5 years) who underwent two thirds anterior corpus callosotomy for treatment of refractory seizures. After 7-13 years follow-up (mean 10.5 years), children experienced a median seizure frequency reduction of 53.1% at one year(n=37), 56.7% at three years(n=37), 54.7% at five years(n=33), and 49.9% at the last follow-up(n=31). In these patients, 48.4% (n=15) had >or=50% seizure reduction, 9.6% (n=3) had seizure free and 19.4% (n=6) had no seizure reduction or even worse at the last follow-up. The complications for corpus callosotomy were 37.8% (2.7% permanent).
[Conclusions] Corpus callosotomy remains to be a safe and effective choice of surgical treatment for children with intractable epilepsy.
[Methodology] A retrospective study evaluated the effectiveness of corpus callosotomy in children with refractory epilepsy. Data collection forms were designed for retrospectively gathering data on each patient’s pre-surgery history, seizures, surgeries, and adverse events.
[Results] We describe 37 children (21 males and 16 females; mean age at surgery: 10.5 years) who underwent two thirds anterior corpus callosotomy for treatment of refractory seizures. After 7-13 years follow-up (mean 10.5 years), children experienced a median seizure frequency reduction of 53.1% at one year(n=37), 56.7% at three years(n=37), 54.7% at five years(n=33), and 49.9% at the last follow-up(n=31). In these patients, 48.4% (n=15) had >or=50% seizure reduction, 9.6% (n=3) had seizure free and 19.4% (n=6) had no seizure reduction or even worse at the last follow-up. The complications for corpus callosotomy were 37.8% (2.7% permanent).
[Conclusions] Corpus callosotomy remains to be a safe and effective choice of surgical treatment for children with intractable epilepsy.