[P2-130] Investigate the effect of antiepileptic drugs on bone metabolism in children with epilepsy
Objective: Understanding of antiepileptic drugs (AEDs):Levetiracetam (LEV), Sodium valproate (VPA), Oxcarbazepine (OXC)， affected the relevant indexes of bone metabolism in children with epilepsy，to explore the possible mechanism,So as to provide theoretical basis for early clinical prevention.
Method: From June 2012 to November 2013, 64 children with epilepsy in our hospital were treated with single drug therapy,more than 6 months.30 cases of healthy children as control group.The four groups were all used automatic biochemical analyzer to detect serum 25 hydroxy vitamin D3
[25(OH)D3], parathyroid hormone (PTH), serum calcium (Ca2 +), serum phosphorus(P3+),serum alkaline phosphatase (ALP) concentration,Ultrasonic bone mineral density measurement (BMD) using 7000Pomnisense instrument.All the patients in the treatment group before taking AEDs, 6 months after the detection of the above indexes, including 45 cases (19 cases LEV group ),( 12 cases VPA group), (14 cases OXC group), in taking more than 12 months were detected ( seizure frequency reduced more than 50%).
Result: 1. AEDs monotherapy in short term (within 6 months) had no significant effect on bone metabolism in children with epilepsy.2. For more than 12 months, AEDs has an impact on the related indexes of bone metabolism, including OXC group and VPA group, the serum ALP increased, BMD decreased, with statistical significance.
Conclusion: In the clinical application of AEDs, the bone metabolism indexes of children with epilepsy should be monitored regularly, and the early intervention should be given when necessary.
Method: From June 2012 to November 2013, 64 children with epilepsy in our hospital were treated with single drug therapy,more than 6 months.30 cases of healthy children as control group.The four groups were all used automatic biochemical analyzer to detect serum 25 hydroxy vitamin D3
[25(OH)D3], parathyroid hormone (PTH), serum calcium (Ca2 +), serum phosphorus(P3+),serum alkaline phosphatase (ALP) concentration,Ultrasonic bone mineral density measurement (BMD) using 7000Pomnisense instrument.All the patients in the treatment group before taking AEDs, 6 months after the detection of the above indexes, including 45 cases (19 cases LEV group ),( 12 cases VPA group), (14 cases OXC group), in taking more than 12 months were detected ( seizure frequency reduced more than 50%).
Result: 1. AEDs monotherapy in short term (within 6 months) had no significant effect on bone metabolism in children with epilepsy.2. For more than 12 months, AEDs has an impact on the related indexes of bone metabolism, including OXC group and VPA group, the serum ALP increased, BMD decreased, with statistical significance.
Conclusion: In the clinical application of AEDs, the bone metabolism indexes of children with epilepsy should be monitored regularly, and the early intervention should be given when necessary.