[P2-131] Short-term application of phenobarbital and topiramate affect s cognition of the immature brain and protective effects of 17- beta estradiol
Abstract:Previous studies have shown that the long-term use of antiepileptic drugs can cause nervous system damage.However, short-term antiepileptic drug treatment is frequently given to fants, especially neonates, to control seizure.In previous study, we showed the short-term use of antiepileptic drugs were cytotoxic to hippocampal CA1 neurons and inhibited the expression of GluR1 and NR2B, which is associated with learning and memory.However, it is necessary for using antiepileptic drugs to control seizure.So, we should findr neuroprotective drugs to diminish the neurotoxicity of antiepileptic drugs.In the present study, immature rats, 3 days of age, were intraperitoneally injected with phenobarbital and topiramate individually, then some of them may injected 17 beta estradiol for protection for 3 consecutive days. Water maze revealed that Short term application of clinical doses of phenobarbital, could cause long-term cognitive impairment, while that of topiramate had no obvious effect.17β-estradiol have protective effect to immature brain damaged by antiepileptic drugs, which provides a new research direction for neural protection to the patients used antiepileptic drugs.