[P2-139] Outcomes and MR imaging in neonates with hypoxia-ischemia encephalopathy treated by hypothermia
[Introduction]
Neonatal hypoxia-ischemia encephalopathy (HIE) is an important issue in the field of pediatrics, and recently, hypothermia therapy has been administered to neonates with moderate to severe HIE. Developmental progress and outcomes of neonates with HIE treated with hypothermia are presented.
[Materials and Methods]
Seven neonates (born at 36-41 gestational weeks, weighing 2,100 g to 3,700 g) with HIE treated with hypothermia were studied.
[Results]
All 7 neonates with HIE underwent magnetic resonance imaging (MRI) during the neonatal period, which showed abnormal signal intensity in the basal ganglia. All patients were observed for several months perinatally and thereafter (follow-up duration: 14 to 27 months). Six of the 7 patients underwent MRI twice during the neonatal period, and 4 showed improvements in abnormal signal intensity while the abnormal signal intensity persisted in the other 2. Five patients showed muscle hypotonia and/or hypertonia in early infancy, but these abnormalities improved in late infancy. Furthermore, after 1 year, gross motor development progress was essentially normal. Two patients with persistent abnormal MRI intensity had hypertonia in early infancy, and were diagnosed with quadriplegia or diplegia.
[Conclusions]
HIE patients, regardless of whether or not they were treated with hypothermia, showed improvements in MRI findings and gross motor development outcomes were relatively good.
Neonatal hypoxia-ischemia encephalopathy (HIE) is an important issue in the field of pediatrics, and recently, hypothermia therapy has been administered to neonates with moderate to severe HIE. Developmental progress and outcomes of neonates with HIE treated with hypothermia are presented.
[Materials and Methods]
Seven neonates (born at 36-41 gestational weeks, weighing 2,100 g to 3,700 g) with HIE treated with hypothermia were studied.
[Results]
All 7 neonates with HIE underwent magnetic resonance imaging (MRI) during the neonatal period, which showed abnormal signal intensity in the basal ganglia. All patients were observed for several months perinatally and thereafter (follow-up duration: 14 to 27 months). Six of the 7 patients underwent MRI twice during the neonatal period, and 4 showed improvements in abnormal signal intensity while the abnormal signal intensity persisted in the other 2. Five patients showed muscle hypotonia and/or hypertonia in early infancy, but these abnormalities improved in late infancy. Furthermore, after 1 year, gross motor development progress was essentially normal. Two patients with persistent abnormal MRI intensity had hypertonia in early infancy, and were diagnosed with quadriplegia or diplegia.
[Conclusions]
HIE patients, regardless of whether or not they were treated with hypothermia, showed improvements in MRI findings and gross motor development outcomes were relatively good.