[P2-141] The clinical features of 5 neonate diagnosed as Mild encephalopathy/encephalitis with a reversible splenial lesion
【Abstract】Objective::To study the clinical features of Mild encephalopathy/encephalitis with a reversible splenial lesion in neonates Methods:Here we describe five cases clinically diagnosed as mild encephalopathy with a reversible splenial lesion. All of them are neonates and the average age is about 4 days. They were admitted for the common neurological symptoms such as hyperspasmia, poor reactivity and delirium. Auxiliary examinations during hospitalization also exhibited features in common. Results: Firstly, magnetic resonance imaging revealed solitary or comprehensive lesions in the splenium of corpus callosum, some of them extending to almost whole of the corpus callosum. The lesions showed low intensity signal on T1-weighted images, homogeneously hyperintense signal on T2-weighted images, fluid-attenuated inversion recovery and diffusion-weighted images, and exhibited an obvious reduced diffusion on apparent diffusion coefficient map. Moreover, the lesions in the magnetic resonance imaging disappeared very quickly even prior to the clinical recovery. Secondly, all the cases depicted here suffered electrolyte disturbances especially hyponatremia which could be easily corrected. Lastly, all of the cases recovered quickly over one week to one month and majority of them exhibited signs of infections (3/5) and normal electroencephalography.Conlusions: There were some common clinical manifestation and features of magnetic resonance imaging in mild encephalopathy/encephalitis with a reversible splenial lesion in neonates.Recognition of these characteristic would help us indentify the diagnosis and treat promptly.