[P2-145] A Study of Periventricular Punctate Lesions on T1-weighted MRI Found in Neonates
We report a clinical study on neonatal periventricular punctate lesions with high intensity on T1-weighted MRI. We retrospectively reviewed the brain MRI of 482 neonates discharged from NICU between January 1, 2011 and December 31, 2012. Eighteen neonates (4%) had the periventricular punctate lesions on T1-weighted MRI. Male-to-female ratio was 10:8. The incidence rate of the lesions was 0% under 28 weeks of PCA, 4% between 28 and 33 weeks of PCA, 5% between 34 and 36 weeks of PCA, and 2% over 36 weeks of PCA. They were found in 5 % of neonates born by vaginal delivery, and 3 % of neonates born by Caesarean section. Apgar score at 5 min of all 18 neonates with punctate lesions was not lower than 7. We found no characteristic background disorders strongly related with the detection of the lesions. They were even found in 2 preterm neonates without any complicated clinical features. The 2nd MRI study was done on 8 infants between 3 weeks and 4 months after the 1st MRI study, and showed disappearance of the lesions in all. Developmental follow-up was done on 9 patients, who walked alone between 11 and 17 months (median: 13 months) of corrected age, and spoke several words between 11 and 19 months (median: 13 months) of corrected age. We concluded that the periventricular punctate lesions in neonates on T1-weighted MRI disappeared in early infancy and showed no striking effects on short-term psychomotor developments. (supported by the grant from Saitama Medical University)