[P2-48] Neurodevelopmental outcome in children with corpus callosal abnormalities
[Introduction] The aim of our study is to evaluate the neurodevelopmental outcomes and associated clinical factors in patients with corpus callosal abnormalities diagnosed by fetal sonography.
[Methodology] Between July 2011 and July 2016, fifty-one children with corpus callosal abnormalities were born in Asan medical center children’s hospital. To assess their neurodevelopmental outcomes, Bayley Scales of Infant Development (BSID-III) or Korean Infant and Child Development Test (KICDT) were conducted at the mean age 34.0 months (6 - 60 months) in 40 patients. Baseline characteristics and developmental outcomes of each groups were compared.
[Results] Twenty patients (39.2%) have isolated agenesis or hypoplasia of the corpus callosum. Twenty-five children (41.2%) were associated with other central nervous system (CNS) anomalies, of which interhemispheric cyst (N = 9, 17.6%) and malformation of cortical development (N = 9, 17.6%) were most common. Non-CNS abnormalities were observed in 10 patients (19.6%). Among 40 patients underwent developmental evaluation, 20 (50%) showed normal development and 13 showed global developmental delay (32.5%). Eleven (78.6%) among the 14 patients with isolated callosal abnormalities showed normal development. Combined CNS anomalies were not significantly associated with global developmental delay. Combined anomalies with non-CNS anomalies were strongly associated with global developmental delay (RR 14.5, CI 2.0-106.2, p = 0.001).
[Conclusions] Children with isolated corpus callosal abnormalities showed favorable neurodevelopmental outcome. However, appropriate evaluation and comprehensive therapeutic approaches are strongly recommended in a neonate who has additional anomalies with corpus callosal abnormalities.
[Methodology] Between July 2011 and July 2016, fifty-one children with corpus callosal abnormalities were born in Asan medical center children’s hospital. To assess their neurodevelopmental outcomes, Bayley Scales of Infant Development (BSID-III) or Korean Infant and Child Development Test (KICDT) were conducted at the mean age 34.0 months (6 - 60 months) in 40 patients. Baseline characteristics and developmental outcomes of each groups were compared.
[Results] Twenty patients (39.2%) have isolated agenesis or hypoplasia of the corpus callosum. Twenty-five children (41.2%) were associated with other central nervous system (CNS) anomalies, of which interhemispheric cyst (N = 9, 17.6%) and malformation of cortical development (N = 9, 17.6%) were most common. Non-CNS abnormalities were observed in 10 patients (19.6%). Among 40 patients underwent developmental evaluation, 20 (50%) showed normal development and 13 showed global developmental delay (32.5%). Eleven (78.6%) among the 14 patients with isolated callosal abnormalities showed normal development. Combined CNS anomalies were not significantly associated with global developmental delay. Combined anomalies with non-CNS anomalies were strongly associated with global developmental delay (RR 14.5, CI 2.0-106.2, p = 0.001).
[Conclusions] Children with isolated corpus callosal abnormalities showed favorable neurodevelopmental outcome. However, appropriate evaluation and comprehensive therapeutic approaches are strongly recommended in a neonate who has additional anomalies with corpus callosal abnormalities.