[P2-66] Central nervous system neuronal surface antibody associated syndrome with infantile spasm and GABABR antibody: a case report
Infantile spasm is a severe epilepsy encephalopathy with age dependence, which has some features such as specific form of convulsion, decreased intelligence development, hyperarrhythmia. It is one kind of intractable epilepsy and many pathogenesis. An autoimmune cause in intractable epilepsy is increasingly recognized by the detection of neural autoantibodies in serum or spinal fluid. The antibodies that bind to cell surface determinants of membrane associated proteins on neuronal cells and are likely to be pathogenic in CNS syndromes are called “neuronal surface antibodies” (NSAbs). The disease associated with them is called NSAb syndromes (NSAS). We describe a case of 17 month, who suffering from IS. Laboratory date revealed OCB(+) ,IgG index (0.93) and MBP(3.62μg/l) increased in spinal fluid and GABABR antibody (+++) in serum. Abnormal signals in bilateral temporal lobe and parietal lobe were detected by MRI. Neuronal surface antibodies and GABABR antibody are suspected one cause of Infantile Spasm.