[P2-83] The Association of Epilepsy and Asthma, A Population-based Retrospective Cohort Study
[Introduction] Little epidemiologic data published to support the association between epilepsy and asthma. In current study, we examined the association between these two disorders. [Methodology] We used claims data obtained from the Taiwan National Health Insurance database to conduct retrospective cohort analyses. Analysis 1 compared 154,284 patients with incident asthma diagnosed in 1996–2013 with controls without the disease randomly selected during the same period, frequency matched with sex and age. Analysis 2 comprised a similar method to compare 25,274 patients with newly diagnosed epilepsy with randomly selected sex- and age-matched controls. At the end of 2013, analysis 1 measured the incidence and risk of developing epilepsy and analysis 2 measured the incidence and risk of developing asthma. Kaplan-Meier estimator was utilized to plot the proportion seizure or asthma free. [Results] In analysis 1, the incidence of epilepsy was higher in the asthma cohort than in the nonasthma cohort (3.14 vs. 1.19 per 1,000 person-years) with an adjusted hazard ratio of 1.37 [95% confidence interval (CI) 1.31–1.44] for asthma patients. The effect of asthma on subsequent epilepsy was greater for women. In analysis 2, the incidence of asthma was no significant difference between epilepsy cohort and nonepilepsy comparison cohort. But we found some age subgroups had positive association, including childhood and thirties. Negative association was found in adolescents. In the Kaplan-Meier curve analysis, we found positive association of epilepsy on subsequent asthma within the early 5 years. [Conclusions] Asthma may be associated with an increase in the risk of future epilepsy. On the other hands, Epilepsy may be associated with an increase in the risk of future asthma occurrence in children and thirties. And other epilepsy age-subgroups should aware of subsequent asthma in the early years after epilepsy been diagnosed.