[P3-11] The Efficacy of Anti-epileptic Drugs for Sleep Disturbance and EEG Abnormality in Developmental Disorders
[Introduction] In pharmacotherapy for developmental disorders, not only anti-psychotic drugs, a combination of anti-epileptic drugs have effective for irritability or sleep disturbance. However, evidence of the efficacy of anti-epileptic drugs in developmental disorders associated with abnormal EEG has not been established. The major aim of this work is to clarify the usefulness of anti-epileptic drugs for irritability or sleep disturbance in children with ASD, ADHD or ID.
[Methodology] A total of 303 children (224 males, 70 females, mean age 13.4（from 3 – 31） years were included in this study. EEG had been recorded every 6 months under sleep conditions. We examined the therapeutic effect of anti-epileptic drug for behavioral, psychiatric problems and sleep disturbance in developmental disorders associated with abnormal EEG. Clinical improvement was evaluated by CGI-I score.
[Results] EEG abnormalities were present in 78.2 %, sleep disturbance was complicated in 33.3% of whole; 41.4% in ASD and 16.4% in ADHD respectively. Epilepsy was present in 48.2%. Almost patients showed EEG abnormalities on frontal areas. The patients treated with the both anti-psychotic drugs (RIS, ARP, MPH, ATX) and anti-epileptic drugs (VPA, CBZ, CZP, LEV, LTG) were more improved sleep disturbance and CGI-I scores. EEG improvement with antiepileptic drug treatment showed a high correlation with behavioral improvements as shown by CGI-I scores.
[Conclusions] Anti-epileptic drug is effective for sleep disturbance in developmental disorders with EEG abnormalities. In cases of EEG abnormalities, anti-epileptic drugs may be an alternative treatment for sleep disturbance in developmental disorders.
[Methodology] A total of 303 children (224 males, 70 females, mean age 13.4（from 3 – 31） years were included in this study. EEG had been recorded every 6 months under sleep conditions. We examined the therapeutic effect of anti-epileptic drug for behavioral, psychiatric problems and sleep disturbance in developmental disorders associated with abnormal EEG. Clinical improvement was evaluated by CGI-I score.
[Results] EEG abnormalities were present in 78.2 %, sleep disturbance was complicated in 33.3% of whole; 41.4% in ASD and 16.4% in ADHD respectively. Epilepsy was present in 48.2%. Almost patients showed EEG abnormalities on frontal areas. The patients treated with the both anti-psychotic drugs (RIS, ARP, MPH, ATX) and anti-epileptic drugs (VPA, CBZ, CZP, LEV, LTG) were more improved sleep disturbance and CGI-I scores. EEG improvement with antiepileptic drug treatment showed a high correlation with behavioral improvements as shown by CGI-I scores.
[Conclusions] Anti-epileptic drug is effective for sleep disturbance in developmental disorders with EEG abnormalities. In cases of EEG abnormalities, anti-epileptic drugs may be an alternative treatment for sleep disturbance in developmental disorders.