[P3-117] Polysomnography Parameters Character and Risk Factors of Sleep Breathing Disorder in Duchenne Muscular Dystrophy Children
[Introduction]: This study aims to analyze sleep breathing parameters and risk factors of sleep breathing disorder (SBD) in Duchenne Muscular Dystrophy(DMD) children.
[Methodology]: DMD Children, finished polysomnography, were retrospectively collected and divided into SBD and non-SBD group. 14 sleep breathing parameters were compared using rank sum test, and 9 risk factors of SBD including physical(overweight, malnutrition, scoliosis, ventricular enlargement, North Star Ambulatory Assessment Score, age of taking PSG, moving with wheelchair) and environmental factors(single-parent family, parents being unemployed) were analyzed using Multi-Logistic Regression Analysis.
[Results]: 70 boys, aged 1~14ys, were included. 66 cases also completed percutaneous carbon dioxide (CO2) monitoring. 25 patients were in SBD group and 45 in non-SBD group. SBD group contained none of 1~3ys patients, 34.8%(8/23) of 4~6ys patients, 40.0%(12/30) of 7~9ys patients, and 100%(5/5) of patients≥10ys. 14 patients diagnosed as Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). 18 cases had CO2 retention. 7 patients had both OSAHS and CO2 retention. As to symptoms, sleep apnea phenomenon, shortness of breath during sleep, opening mouth during sleep and daytime drowsiness presented more often in SBD group(P<0.05). As to sleep parameters, SBD group had more wake-up time, more awake with events, more light sleep, less deep sleep, and lower sleep efficiency(P<0.05). As to respiratory parameters, SBD group patients had higher obstructive apnea index, hypopnea index, obstructive apnea/hypopnea index, oxygen desaturation index, mean partial pressure of CO2, and lower blood oxygen saturation. North Star Ambulatory Assessment Score<13.5 (OR=3.4, 95%CI: 1.060-10.949) and age of taking PSG≥6ys (OR=7.3, 95%CI: 1.426-37.463) increased the risk of suffering SBD.
[Conclusions]: SBD occurs in early course of DMD. The risk of SBD increased with age. Motor function assessment can be a good predictor of SBD
[Methodology]: DMD Children, finished polysomnography, were retrospectively collected and divided into SBD and non-SBD group. 14 sleep breathing parameters were compared using rank sum test, and 9 risk factors of SBD including physical(overweight, malnutrition, scoliosis, ventricular enlargement, North Star Ambulatory Assessment Score, age of taking PSG, moving with wheelchair) and environmental factors(single-parent family, parents being unemployed) were analyzed using Multi-Logistic Regression Analysis.
[Results]: 70 boys, aged 1~14ys, were included. 66 cases also completed percutaneous carbon dioxide (CO2) monitoring. 25 patients were in SBD group and 45 in non-SBD group. SBD group contained none of 1~3ys patients, 34.8%(8/23) of 4~6ys patients, 40.0%(12/30) of 7~9ys patients, and 100%(5/5) of patients≥10ys. 14 patients diagnosed as Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). 18 cases had CO2 retention. 7 patients had both OSAHS and CO2 retention. As to symptoms, sleep apnea phenomenon, shortness of breath during sleep, opening mouth during sleep and daytime drowsiness presented more often in SBD group(P<0.05). As to sleep parameters, SBD group had more wake-up time, more awake with events, more light sleep, less deep sleep, and lower sleep efficiency(P<0.05). As to respiratory parameters, SBD group patients had higher obstructive apnea index, hypopnea index, obstructive apnea/hypopnea index, oxygen desaturation index, mean partial pressure of CO2, and lower blood oxygen saturation. North Star Ambulatory Assessment Score<13.5 (OR=3.4, 95%CI: 1.060-10.949) and age of taking PSG≥6ys (OR=7.3, 95%CI: 1.426-37.463) increased the risk of suffering SBD.
[Conclusions]: SBD occurs in early course of DMD. The risk of SBD increased with age. Motor function assessment can be a good predictor of SBD