[P3-125] Relationship between Impedance Obtained by BIA and MR images of Lower Limbs of Patients with Fukuyama Congenital Muscular Dystrophy
[Background]
With the advancement of research on the treatment of Fukuyama muscular dystrophy (FCMD), safe testing methods with less burden on patients have been required. We have reported that a muscle quantitative index measured by BIA can be used to determine skeletal muscle mass and the severity of FCMD. In this study, we examined the relationship between time-course changes in impedance obtained by BIA and signal intensities in STIR MR images of FCMD patients, focusing on the observation of transient high signal intensities in the images of patients in their developmental period.
[Subjects]
The subjects included 18 FCMD patients (age: 7 months–13 years and 4 months) who underwent lower-limb STIR MR imaging and BIA between March 2012 and August 2015.
[Methodology]
The changes in impedance muscle density index (MDI) was obtained by BIA and signal intensities in the STIR MR imaging were examined retrospectively on the basis of the medical records of the patients.
[Results]
MDI of patients peaked at approximately three years of age and decreased afterward. Once MDI started to decrease, joint contracture became apparent even in the presence of motor development. In the patients without clear contracture of the hip, knee, or ankle joints, high signal intensities in STIR MR images of the thigh extensor group and soleus muscles were observed when the MDI started to decrease.
[Conclusions]
MDI can serve as a parameter of contracture in FCMD patients because the increase in the number of connective tissues indicates the advancement of contracture.
With the advancement of research on the treatment of Fukuyama muscular dystrophy (FCMD), safe testing methods with less burden on patients have been required. We have reported that a muscle quantitative index measured by BIA can be used to determine skeletal muscle mass and the severity of FCMD. In this study, we examined the relationship between time-course changes in impedance obtained by BIA and signal intensities in STIR MR images of FCMD patients, focusing on the observation of transient high signal intensities in the images of patients in their developmental period.
[Subjects]
The subjects included 18 FCMD patients (age: 7 months–13 years and 4 months) who underwent lower-limb STIR MR imaging and BIA between March 2012 and August 2015.
[Methodology]
The changes in impedance muscle density index (MDI) was obtained by BIA and signal intensities in the STIR MR imaging were examined retrospectively on the basis of the medical records of the patients.
[Results]
MDI of patients peaked at approximately three years of age and decreased afterward. Once MDI started to decrease, joint contracture became apparent even in the presence of motor development. In the patients without clear contracture of the hip, knee, or ankle joints, high signal intensities in STIR MR images of the thigh extensor group and soleus muscles were observed when the MDI started to decrease.
[Conclusions]
MDI can serve as a parameter of contracture in FCMD patients because the increase in the number of connective tissues indicates the advancement of contracture.