[P3-160] Nerve Regeneration After Severe Trauma
[Background]: Although many experimental studies about nerve regeneration achieved encouraging progress, neurologic deficits still remain following trauma nerve damage in clinical patients. [Methods]: We reported a case of a 2-year-old female who was injured in an accidental bullet train crash. Her left lower limb suffered from crush injury for one month, and her nerves of left lower limb were severely damaged. After admission, for nerve regeneration: in the early period of treatment, nerve growth factor combined with ganglioside and multiplex vitamins were used. One surgical debridement was repeatedly performed for removal of necrotic tissues; Antibiotics was used to prevent infection; [Results]: After two months of treatment, clinical and electrophysiological evidence of signs of recovery among sensory, motor and sympathetic functions of the left tibial nerve and peroneal nerve and associated left lower limb muscles was demonstrated. Her multiple wounds of left lower limb healed. The patient then accepted rehabilitation training. Meanwhile, nerve growth factor combined with multiplex vitamins was continuously applied, and then in later period, only multiplex vitamins were reserved. Finally, the sensory, motor and sympathetic functions of left lower limb nerves including tibial nerve, peroneal nerve and sural nerve were much improved. The function of the patient’s left lower limb was close to normal after 20 months of treatment. [Conclusion]: the case support the hypothesis that nerve nutrition therapy with nerve growth factor, ganglioside combined with multiplex vitamins might be more beneficial to improve nerve regeneration and repair on the basis of debridement and prevention of infection.