[P3-191] Impaired Glucose Tolerance among Children, Adolescents, and Young Adults with Circadian Rhythm Sleep Disorder
[Background and Objective]The essential feature of circadian rhythm sleep disorder (CRSD) is not simply a sleep disturbance due to alterations in the circadian clock system but a relevant disturbance of the physiology, endocrinology and metabolism. The primary purposes of the present study were to assess glucose tolerance and insulin sensitivity and to examine these associations with sleep quality, sleep quantity and biological circadian rhythm in children, adolescents, and young adults with CRSD.
[Methodology]We recruited 129 subjects (8 to 25 years of age) who had admitted for treatment of sleep disturbances to Hyogo Children's Sleep and Development Medical Research Center between 2009 and 2011. All subjects underwent a three-hour oral glucose tolerance test (1.75mg/kg to a maximum 75g). The sum of PGs (ΣPG), the sum of IRIs (ΣIRI), insulinogenic index, and homeostasis model assessment ratio (HOMA-R) were calculated. Polysomnography was performed and core body temperature was sampled in all subjects. Findings were compared and statistically analyzed between patients with IGT and those with normal glucose tolerance (NGT).
[Results]IGT was detected in 22.2 % of 108 subjects without obesity and hypertriglyceridemia. ΣPG, ΣIRI, and ketone levels were significantly greater in patients with IGT. No differences existed in parameters of polysomnography. Circadian rhythm of core body temperature among subjects with IGT were tend to be disrupted.[Conclusions]IGT, which was associated with insulin resistance, was highly prevalent among children, adolescents and young adults with CRSD. We need further study to elucidate how sleep disturbances and disruption of biological rhythm increase the prevalence of IGT
[Methodology]We recruited 129 subjects (8 to 25 years of age) who had admitted for treatment of sleep disturbances to Hyogo Children's Sleep and Development Medical Research Center between 2009 and 2011. All subjects underwent a three-hour oral glucose tolerance test (1.75mg/kg to a maximum 75g). The sum of PGs (ΣPG), the sum of IRIs (ΣIRI), insulinogenic index, and homeostasis model assessment ratio (HOMA-R) were calculated. Polysomnography was performed and core body temperature was sampled in all subjects. Findings were compared and statistically analyzed between patients with IGT and those with normal glucose tolerance (NGT).
[Results]IGT was detected in 22.2 % of 108 subjects without obesity and hypertriglyceridemia. ΣPG, ΣIRI, and ketone levels were significantly greater in patients with IGT. No differences existed in parameters of polysomnography. Circadian rhythm of core body temperature among subjects with IGT were tend to be disrupted.[Conclusions]IGT, which was associated with insulin resistance, was highly prevalent among children, adolescents and young adults with CRSD. We need further study to elucidate how sleep disturbances and disruption of biological rhythm increase the prevalence of IGT