[P3-199] A Case Report of a Mature Teratoma of the Pineal Gland in a Nine-year-old Male
Intracranial teratomas account for 0.5% of all intracranial tumors and 2-4% of intracranial tumors in children. However, in terms of tumors of the pineal area, the exact incidence is not ascertained. Although, it is noted that 50-60% of CNS germ cell tumors are found in the pineal gland. The degree of difficulty in the sampling of lesions in the pineal gland during biopsy emphasizes the importance of correlating the imaging studies, histopathologic findings, and serum and CSF tumor markers. This is a case report of a 9-year-old male who presented with frontal headache of eight days, with associated photophobia, nausea and vomiting, and diplopia. Biopsy with intraoperative navigation was done and the specimen was referred for histopathologic evaluation, which showed findings consistent with a mature teratoma with no histologic findings of an immature component or secondary somatic malignancy. Comparison with the post-operative imaging cranial CT-scan showed findings representative of a residual tumor. This is correlated with the pre-operative serum tumor markers which showed alpha-fetoprotein of 22.5 ng/mL (normal values: 1.45-8.47 ng/mL) and beta-HCG of 1.0 mIU/mL (normal values: 0-5 mIU/mL), and the tumor markers of the cerebrospinal fluid that showed alpha-fetoprotein of 3.28 ng/mL (normal values: 1.45-8.47 ng/mL) and beta-HCG of 18.9 mIU/mL (normal values: 0-5 mIU/mL). Comparison of the findings of this case with reports in scientific publication is done to correlate the histopathologic, serum and CSF findings, and imaging studies, to contribute to the information in explaining the mechanisms of the disease.