[P3-5] fNIRS-based assessment of individual classification of ADHD children by right prefrontal hemodynamic responses during an inhibition task
[Objective] An objective biomarker for the diagnosis of ADHD has not been established. In our previous functional near-infrared spectroscopy (fNIRS)-based studies, we have successfully visualized the hypoactivation pattern in the right prefrontal cortex during an inhibition task in ADHD children compared with typically developing (TD) control children at a group level. The current study aimed to explore a method of individual differentiation between ADHD and TD children using multichannel fNIRS, emphasizing how spatial distribution and amplitude of hemodynamic response are associated with inhibition-related right prefrontal dysfunction.
[Methods] Thirty right-handed ADHD children (mean age: 9.1 yr., range: 6-15 yr.) with IQ＞70 and TD age-matched children underwent an inhibition task, and their cortical hemodynamics were assessed using fNIRS. We explored specific regions of interest (ROIs) and cut-off amplitudes for cortical activation to distinguish ADHD children from TD children. Written consent was obtained from all subjects. The study was authorized by the applicable ethics committees.
[Results] The ROI located on the border of the right inferior and middle frontal gyri (IFG/MFG). At the optimal cut-off value of 0.0111 mM/mm, differentiation was achieved with an area under the curve value of 85% and with 90% sensitivity.
[Discussion]The fNIRS-based measurements were simple and sufficiently robust, including subjects as young as 6 years. Hypoactivation of the right IFG/MFG assessed by fNIRS during an inhibition task would serve as a potentially effective biomarker for classifying ADHD children at the individual level.
[Methods] Thirty right-handed ADHD children (mean age: 9.1 yr., range: 6-15 yr.) with IQ＞70 and TD age-matched children underwent an inhibition task, and their cortical hemodynamics were assessed using fNIRS. We explored specific regions of interest (ROIs) and cut-off amplitudes for cortical activation to distinguish ADHD children from TD children. Written consent was obtained from all subjects. The study was authorized by the applicable ethics committees.
[Results] The ROI located on the border of the right inferior and middle frontal gyri (IFG/MFG). At the optimal cut-off value of 0.0111 mM/mm, differentiation was achieved with an area under the curve value of 85% and with 90% sensitivity.
[Discussion]The fNIRS-based measurements were simple and sufficiently robust, including subjects as young as 6 years. Hypoactivation of the right IFG/MFG assessed by fNIRS during an inhibition task would serve as a potentially effective biomarker for classifying ADHD children at the individual level.