[P3-52] Efficacy of Thyrotropin-releasing Hormone Therapy for Lennox-Gastaut Syndrome
Lennox-Gastaut syndrome (LGS) is intractable epilepsy with tonic seizure and other diverse seizures. Herein we report effectiveness of thyrotropin-releasing hormone (TRH) therapy on five patients with LGS. We administered 0.5-1.0mg/day of TRH for 2-3 weeks intramuscularly.
The present age of the patients was from 4 to 33 years (median 15 years), and two males and three females. Age at seizure onset was from 7 months to 4 years (median 1 year), and age at diagnosis of LGS was from 3 to 11 years (median 6 years). The wide variety of epileptic drugs were used, and the total number of drugs tried before the diagnosis of LGS was from 2 to 8 (median 7). The median number of drugs using at the diagnosis of LGS was 4 (2-6). A period from diagnosis of LGS to start of TRH therapy was a week to 6 months (median one month) and most patients were started within one month. All patients achieved significant reduction of seizure frequency within several months after TRH therapy. Four patients have been seizure free. The EEG findings were also improved in all patients. No side effects were observed. Although one patient showed significant improvement during TRH therapy, some patients showed effects three to four months later. TRH therapy could be a safe and useful treatment for LGS.
The present age of the patients was from 4 to 33 years (median 15 years), and two males and three females. Age at seizure onset was from 7 months to 4 years (median 1 year), and age at diagnosis of LGS was from 3 to 11 years (median 6 years). The wide variety of epileptic drugs were used, and the total number of drugs tried before the diagnosis of LGS was from 2 to 8 (median 7). The median number of drugs using at the diagnosis of LGS was 4 (2-6). A period from diagnosis of LGS to start of TRH therapy was a week to 6 months (median one month) and most patients were started within one month. All patients achieved significant reduction of seizure frequency within several months after TRH therapy. Four patients have been seizure free. The EEG findings were also improved in all patients. No side effects were observed. Although one patient showed significant improvement during TRH therapy, some patients showed effects three to four months later. TRH therapy could be a safe and useful treatment for LGS.