[P3-90] Association of Rs2040946 Genetic Polymorphism in Brain-derived Neurotrophic Factor Gene with Tourette Syndrome of Children in Chinese Han Population
[Introduction] Brain-derived neurotrophic factor (BDNF) is a potential gene for screening Tourette Syndrome (TS).
[Methodology] A case-control study was performed to assess whether both BDNF gene polymorphisms (rs988748 and rs2049046) could be implicated in vulnerability to TS in the Chinese children. The Sequenom®MassARRAY IPLEX GOLD System was performed for genotyping in 151 TS cases and 124 control subjects.
[Results] Allele, genotype and haplotype frequencies of the two polymorphisms were not significantly different when comparing TS and controls (P>0.025). Nevertheless, TS children with severe tic symptoms had significant higher frequencies of rs2040946 T allele and TT genotype than did the normal controls (OR=1.746, 95%CI, 1.216-2.507; P=0.002 after Bonferroni correction; OR=1.746, 95%CI, 1.216-2.507; P=0.002 after Bonferroni correction).
[Conclusions] The T allele and TT genotype of rs2040946 might be the potential genetic risk factors for TS patients with a high severity score in the Chinese Han population. Our findings suggested that this neurotrophin might be involved in the vulnerability to develop TS.
[Methodology] A case-control study was performed to assess whether both BDNF gene polymorphisms (rs988748 and rs2049046) could be implicated in vulnerability to TS in the Chinese children. The Sequenom®MassARRAY IPLEX GOLD System was performed for genotyping in 151 TS cases and 124 control subjects.
[Results] Allele, genotype and haplotype frequencies of the two polymorphisms were not significantly different when comparing TS and controls (P>0.025). Nevertheless, TS children with severe tic symptoms had significant higher frequencies of rs2040946 T allele and TT genotype than did the normal controls (OR=1.746, 95%CI, 1.216-2.507; P=0.002 after Bonferroni correction; OR=1.746, 95%CI, 1.216-2.507; P=0.002 after Bonferroni correction).
[Conclusions] The T allele and TT genotype of rs2040946 might be the potential genetic risk factors for TS patients with a high severity score in the Chinese Han population. Our findings suggested that this neurotrophin might be involved in the vulnerability to develop TS.