[PS15-2C-1] Cerebral Palsy: An update regarding current concepts of the etiology
Cerebral Palsy (CP ) describes a group of disorders of the development of movement and posture that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders are often accompanied by disturbances of sensation , cognition, communication, perception, behavior and seizure disorder. It is a life long disability associated with considerable personal , familial and social burdens.
CP is heterogeneous condition with variety of clinical subtypes , associated neurologic abnormalities ,in particular mental retardation and epilpeptic disorders and various neuroimaging patterns.
Despite major changes in the medical knowledge both in obstetrics and neonatal medicine reflected by better follow up during the pregnancies as well as advanced post natal care in the neonatal intensive care units the over all prevalence of CP throughout the world , where population data are available remains unchanged in the last several decades around 2-2.5/1000 live births.
Traditionally, in 80% of the cases, features were identified pointing to antenatal factors causing abnormal brain development. Fewer than 10% of the children with CP had evidence of intra partum asphyxia.
In the recent decades ,the prevalence of CP is significantly increased among premature lowbirth infants , particularly those weighing <1000 gram at birth.
Recent genetic studies using new generation exome sequencing show that significant percentage of CP cases have likely causative single-gene mutations.
CP is heterogeneous condition with variety of clinical subtypes , associated neurologic abnormalities ,in particular mental retardation and epilpeptic disorders and various neuroimaging patterns.
Despite major changes in the medical knowledge both in obstetrics and neonatal medicine reflected by better follow up during the pregnancies as well as advanced post natal care in the neonatal intensive care units the over all prevalence of CP throughout the world , where population data are available remains unchanged in the last several decades around 2-2.5/1000 live births.
Traditionally, in 80% of the cases, features were identified pointing to antenatal factors causing abnormal brain development. Fewer than 10% of the children with CP had evidence of intra partum asphyxia.
In the recent decades ,the prevalence of CP is significantly increased among premature lowbirth infants , particularly those weighing <1000 gram at birth.
Recent genetic studies using new generation exome sequencing show that significant percentage of CP cases have likely causative single-gene mutations.