[S2-1B-3 ] Enterovirus 71 and Acute Flaccid Paralysis
Enterovirus 71 (EV 71) has been associated with sporadic cases and large outbreaks and has a worldwide distribution. It is one of very few viruses that cause hand, foot, and mouth disease as well as a variety of neurologic manifestations, including aseptic meningitis, encephalitis, acute flaccid paralysis (AFP), Guillain-Barre syndrome, acute transverse myelitis, acute cerebellar ataxia, opsoclonus myoclonus syndrome, benign intracranial hypertension, and febrile convulsion.
Several decades ago, acute poliovirus infection was the most common etiology of AFPin infants and children. In 1988, the World Health Assembly adopted a resolution calling for global eradication of poliomyelitis by the year 2000. With the eradication of circulating wild poliovirus, other nonpolio enteroviruses, including coxsackieviruses, echoviruses, and enteroviruses, are being more commonly identified as the cause of poliomyelitis-like paralysis in AFP surveillance. Among these, EV 71 has replaced poliovirus as the most common likely viral cause of AFP.
Clinical outcomes of EV 71 infection-related polio-like paralytic illness display diverse features, such as complete recovery, residual weakness, persistent flaccid paralysis, and death.This talk will review the epidemiology and motor function outcome of EV 71 infection-related AFP.
Several decades ago, acute poliovirus infection was the most common etiology of AFPin infants and children. In 1988, the World Health Assembly adopted a resolution calling for global eradication of poliomyelitis by the year 2000. With the eradication of circulating wild poliovirus, other nonpolio enteroviruses, including coxsackieviruses, echoviruses, and enteroviruses, are being more commonly identified as the cause of poliomyelitis-like paralysis in AFP surveillance. Among these, EV 71 has replaced poliovirus as the most common likely viral cause of AFP.
Clinical outcomes of EV 71 infection-related polio-like paralytic illness display diverse features, such as complete recovery, residual weakness, persistent flaccid paralysis, and death.This talk will review the epidemiology and motor function outcome of EV 71 infection-related AFP.