[SP2-2F-4] The Clinical Outcomes of Japanese Encephalitis Admitted at Philippine Children’s Medical Center From 2011-2015
Background: Japanese Encephalitis (JE) is the most common vaccine-preventable cause of viral encephalitis in Asia. The reported case-fatality rate is approximately 20-30%, while neuropsychiatric sequelae have been reported in 30-50% of cases. At present, there are no recently published local data regarding the clinical outcome and extent of disability of patients with proven JE.
Objective: The study aims to describe clinical outcomes of laboratory proven Japanese Encephalitis admitted from 2011-2015 at Philippine Children’s Medical Center using the Liverpool Outcome Score Tool and determine possible factors that could influence the outcome.
Methodology: A chart review of 16 laboratory confirmed Japanese Encephalitis using IgM captured ELISA was done. Clinical manifestations and laboratory findings were determined. Eleven of the 16 patients were located for outcome scoring using the Liverpool Outcome Score Tool. The factors such as nutritional status, anemia, co-existing medical condition and the duration of hospital stay were correlated with the outcome score.
Results: The findings in this study were similar from the reported literature and reviews of Japanese Encephalitis. Fever was present in all patients. Decreased sensorium and seizures were still the most common neurologic manifestations. The mortality rate was 18%, while neuropsychiatric sequelae ranging from mild to severe were seen in 45% of the patients. The factors that may have affected the outcome were not significant.
Conclusion: The study established the burden of the disease. These relevant data support the need for health programs on awareness and prevention, especially in endemic areas.
Objective: The study aims to describe clinical outcomes of laboratory proven Japanese Encephalitis admitted from 2011-2015 at Philippine Children’s Medical Center using the Liverpool Outcome Score Tool and determine possible factors that could influence the outcome.
Methodology: A chart review of 16 laboratory confirmed Japanese Encephalitis using IgM captured ELISA was done. Clinical manifestations and laboratory findings were determined. Eleven of the 16 patients were located for outcome scoring using the Liverpool Outcome Score Tool. The factors such as nutritional status, anemia, co-existing medical condition and the duration of hospital stay were correlated with the outcome score.
Results: The findings in this study were similar from the reported literature and reviews of Japanese Encephalitis. Fever was present in all patients. Decreased sensorium and seizures were still the most common neurologic manifestations. The mortality rate was 18%, while neuropsychiatric sequelae ranging from mild to severe were seen in 45% of the patients. The factors that may have affected the outcome were not significant.
Conclusion: The study established the burden of the disease. These relevant data support the need for health programs on awareness and prevention, especially in endemic areas.