[SP2-2F-5] Clinical spectrum and predictive factors of neurological manifestation in children with severe dengue infection in Pediatric Intensive Care Unit (PICU)
[Introduction] Dengue infection has a broad clinical manifestation with recently coined term by WHO, Expanded Dengue Syndrome, which includes neurological manifestation as one of the features. The manifestation are heterogeneous ranging from febrile seizure, encephalitis, encephalopathy, stroke, and Guillain-Barré syndrome. Neurological manifestations are increasingly reported and appear as challenges for medical practice. However, the exact prevalence and predictive factors are still unclear.
[Method] This is a cross-sectional study of patients with severe dengue infection admitted to PICU in a private hospital located in highly populated urban area of Jakarta during August 2015 to August 2016. Diagnosis of all one-month to eighteen-years old patients are based on the clinical findings confirmed with the laboratory test and management of cases are per standard protocol. Children with neurological manifestations are documented and analyzed for relation to several predictive factors.
[Results] There were 56 children in this study and 6 (10,7%) were reported with neurological manifestations. Altered mental status was the most reported and found to happen during the critical phase. Seizures are widely reported with 1 simple febrile seizure, 1 dengue encephalopathy with seizures in the recovery phase, and 1 suspected dengue encephalitis. There is no significant correlation between age, gender, lowest thrombocytes count, increase of hematocrit level, and electrolyte imbalance to the presentation of neurological manifestation.
[Conclusion] 10,7% children with severe dengue infection develop neurological manifestation and various features are reported. Predictive factors to neurological manifestations have not be found in this study and are potential to be investigated.
[Method] This is a cross-sectional study of patients with severe dengue infection admitted to PICU in a private hospital located in highly populated urban area of Jakarta during August 2015 to August 2016. Diagnosis of all one-month to eighteen-years old patients are based on the clinical findings confirmed with the laboratory test and management of cases are per standard protocol. Children with neurological manifestations are documented and analyzed for relation to several predictive factors.
[Results] There were 56 children in this study and 6 (10,7%) were reported with neurological manifestations. Altered mental status was the most reported and found to happen during the critical phase. Seizures are widely reported with 1 simple febrile seizure, 1 dengue encephalopathy with seizures in the recovery phase, and 1 suspected dengue encephalitis. There is no significant correlation between age, gender, lowest thrombocytes count, increase of hematocrit level, and electrolyte imbalance to the presentation of neurological manifestation.
[Conclusion] 10,7% children with severe dengue infection develop neurological manifestation and various features are reported. Predictive factors to neurological manifestations have not be found in this study and are potential to be investigated.