[G101-2am] 17. Biofunctional Chemistry, Biotechnology

[G101-2am-04] Staple oligomer hijacks protein translation machinery based on the conformational changes of mRNA structure

^○Takuto Kamura¹, Yousuke Katsuda¹, Taishi Nakamura^2,3, Kenichi Tsujita³, Yusuke Kitamura¹, Masaki Hagihara⁴, Shin-ichi Sato⁵, Toshihiro Ihara¹ (1. Faculty of Advanced Science and Technology, Kumamoto University, 2. Department of Medical Information Sciences and Administration Planning, Kumamoto University Hospital, 3. Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, 4. Faculty of Science and Technology, Hirosaki University, 5. Institute for Chemical Research, Kyoto University)

[Lang.] English

Keywords:RNA G-quadruplex, Staple oligomer, Suppression of gene expression, Off target effect, Next generation nucleic acid medicine