[G101-3pm] 17. Biofunctional Chemistry, Biotechnology

[G101-3pm-08] Membrane permeable oligonucleotide (MPON) modified with disulfide units induces efficient exon skipping through enhanced membrane permeability and nucleus internalization

^○Haruka Hiraoka¹, Zhaoma Shu¹, Bao Tri Le², Keiko Masuda³, Kosuke Nakamoto¹, Kotaro Hayashi⁴, Naoko Abe¹, Yasuaki Kimura¹, Rakesh N. Veedu², Yoshihiro Shimizu³, Satoshi Uchida⁵, Hiroshi Abe^1,3,6 (1. Nagoya Univ., 2. Murduch Univ., 3. RIKEN, 4. iCONM, 5. Kyoto Pref. Univ. of Med., 6. iGCORE)

[Lang.] Japanese

Keywords:Nucleic acid drug, Antisense DNA, Disulfide modification, Exon skipping