[D1441-4am] 17. Biofunctional Chemistry, Biotechnology

[D1441-4am-06] Novel Design Strategy of DNA-Artificial Nucleic Acid Chimera Toward Enhancement of Target RNA Cleavage Activities: Modification Effects of DNA Moiety upon Complex Stabilities and Activity

^○Nozomu Ishiwata¹, Masahito Inagaki², Masaki Nishijima¹, Hironori Hayashi³, Yasuyuki Araki¹, Eiichi Kodama³, Takehiko Wada¹ (1. IMRAM, Tohoku Univ., 2. Nagoya Univ., 3. IRIDeS, Tohoku Univ.)

[Lang.] Japanese

Keywords:Oligonucleotide therapeutics, RNase H, Catalytic, RNA cleavage, Peptide ribonucleic acid