[E1661-2am] 17. Biofunctional Chemistry, Biotechnology

[E1661-2am-05] Development of second generation NASA warhead for covalent inhibitors

^○Masaharu Kawano¹, Shunsuke Murakawa¹, Tomonori Tamura¹, Itaru Hamachi^1,2 (1. Graduate School of Engineering, Kyoto University, 2. ERATO JST)

[Lang.] English

Keywords:Covalent inhibitors, N-aryl-N-acyl sulfonamide, electrophilic warhead, Structure activity relationship, high selectivity