[E1661-3vn] 17. Biofunctional Chemistry, Biotechnology

[E1661-3vn-04] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (82) : Applications of nearest-neighbor parameters for RNA/DNA hybrid duplexes in the advancement of therapeutics

^○Dipanwita Banerjee¹, Hisae Tateishi-Karimata¹, Saptarshi Ghosh¹, Shuntaro Takahashi¹, Tatsuya Ohyama¹, Tamaki Endoh¹, Maria Toplishek², Marko Trajkovski ², Janez Plavec^2,3,4, Naoki Sugimoto^1,5 (1. FIBER, Konan University, 2. Slovenian NMR Centre, National Institute of Chemistry, 3. EN→FIST Centre of Excellence, 4. Faculty of Chemistry and Chemical Technology, University of Ljubljana, 5. FIRST, Konan University)

[Lang.] English

Keywords:RNA/DNA hybrid duplex, molecular crowding, stability prediction, nearest-neighbor model, CRISPR-Cas9