8:58 AM - 9:23 AM
[IRS-02] Skeletal muscle atrophy-driven facilitation of dementia onset: Mechanism and prevention of the phenomenon
Keywords:骨格筋萎縮、認知症、マイオカイン
The relationship between sarcopenia and cognitive function has been shown to be negatively correlated by the cross-sectional study of healthy old men and meta-analysis. No obvious evidences show that skeletal muscle atrophy directly induces cognitive impairment. We hypothesized that some molecules traveling from the atrophied skeletal muscles to the brain may affect the brain function. Our data revealed that the disuse-induced skeletal muscle atrophy shifted the onset of memory dysfunction earlier in young mice model of Alzheimer’s disease. The atrophied muscles secreted hemopexin, and it was transported to the brain. Infusion of hemopexin in the brain or disuse-induced muscle atrophy impaired memory function and elevated neuroinflammatory factor, lipocalin-2 in hippocampal neurons. This study is the first to demonstrate that skeletal muscle atrophy triggers memory loss. We are investigating the possibility of preventing the onset of dementia by inhibiting hemopexin or other drugs.