[20p-B401-1~12] 7.3 Micro/Nano patterning and fabrication

△ [20p-B401-1] Femtosecond laser formed nanostructures on PLA surface for control of cell elongation

〇Keisuke Takenaka¹, Masahiro Tsukamoto², Takahiro Ooga¹, Yuji Sato², Tsubasa Seike³, Minoru Yoshida³, Kensuke Murai⁴, Satoru Asai¹ (1.Grad.Sch of Eng., Osaka Univ., 2.JWRI, Osaka Univ., 3.Sci and Eng., Kindai Univ., 4.AIST Kansai)

Keywords:femtosecond laser, Poly-lactic-acid, control of cell elongation

Poly-lactic-acid (PLA) has been widely used as biomaterial. In order to add a new function to PLA, we developed a method to form periodic nanostructures on PLA film surface by femtosecond laser irradiation with a wavelength of 800 nm. Since PLA had a low absorbance of light in the near-infrared wavelength region, it was difficult to form the structures by femtosecond laser irradiation on PLA surface. We proposed a method that the femtosecond laser was focused on a titanium (Ti) plate surface through a polymer plate. A cell cultivation test was carried out on PLA plate with and without periodic nanostructures. Consequently, although cells (MG-63) on the non-irradiated PLA plate were spread in a random direction, cell spreading on the PLA plate with periodic nanostructures occurs along the grooves.