[10p-S402-1~18] 12.7 Biomedical Engineering and Biochips

△ [10p-S402-4] The transdermal vaccine delivery by iontophoresis using porous microneedle

〇Natsumi Kimura¹, Reiji Segawa², Shinya Kusama¹, Hiroya Abe^1,3, Matsuhiko Nishizawa¹ (1.Graduate School of Engineering, Tohoku Univ., 2.School of Engineering, Tohoku Univ., 3.FRIS, Tohoku Univ.)

Keywords:microneedle, vaccine, iontophoresis

Recently, iontophoresis has attracted much attention as a method of vaccine administration. In this study, a negatively charged porous microneedle array (PMN) was fabricated by a modification of polymer onto the surface, which enabled to penetrate into the stratum corneum and conduct electricity. The negatively charged PMN can induce the electroosmotic flow by applying voltage. Compared with a passive release from an unmodified PMN, an injection of fluorescent-labeled ovalbumin (OVA), used as a vaccine-model, was successfully accelerated using the negatively charged PMN.