[13a-N202-1~12] 3.4 Biomedical optics

△ [13a-N202-9] High-sensitivity Raman imaging of non-alcoholic fatty liver disease model using surface-enhanced Raman spectroscopy

〇(M2)Hiroki Tanioka¹, Takeo Minamikawa^1,2, Mayuko Ichimura-Shimizu³, Yuki Morimoto³, Hiroki Takanari², Yutaro Onishi¹, Eiji Hase², Takeshi Yasui^1,2, Koichi Tsuneyama^2,3 (1.Grad. Sch. of Sci. Tech., Tokushima Univ., 2.pLED, Tokushima Univ., 3.Grad. Sch. of Biomed. Sci., Tokushima Univ.)

Keywords:non-alcoholic fatty liver disease, surface-enhanced Raman spectroscopy

Since Raman scattered light is extremely weak, it poses a major problem in elucidating the pathological mechanism of NAFLD and realizing a practical diagnostic method. Therefore, in this study, high-sensitivity Raman imaging of the NAFLD model was performed by applying SERS spectroscopy using the light-enhancing effect of the plasmon phenomenon of metal nanoparticles. As a result, signal light enhancement of 10 times or more can be obtained, which may lead to elucidation of the pathological mechanism of NAFLD and development of a practical diagnostic method.