[15a-A405-1~8] 3.3 Biomedical optics (formerly 3.4)

[15a-A405-6] Experimental depth estimation of cancer invasion using scattering of circularly polarized light

〇Nozomi Nishizawa¹, Takahiro Kuchimaru² (1.Kitasato Univ., 2.Jichi Med. Univ.)

Keywords:Circularly polarized light, Cancer estimation, Multiple scattering

Quantitative depth of tumor invasion in early gastric cancer cases via the scattering of circularly polarized light was computationally and experimentally estimated. Invasion depth information of cancer in early stage is very beneficial for cancer diagnosis. The circularly polarized light scattering method can provide depth profiles by varying the incident or detection angles as well as wavelengths of circularly polarized light. Incident circularly polarized light is gradually depolarized owing to multiple scattering against cell nuclei in biological tissues. Since the degree of depolarization significantly depends on the size and shape of the scattering particles, the enlargement of cell nuclei in the scattering volume due to cancerization can be investigated by assaying the polarization of scattered light. This paper reports the experimental results with bilayered biological tissues to demonstrate cancer depth estimation using this technique.