[15p-B508-1~18] 12.2 Characterization and Materials Physics

△ [15p-B508-9] Quantitative microscopic observation of single-molecular aggregation state using of single-molecule measurement

〇Yuki Komoto¹, Yusuke Takashima¹, Takahito Ohshiro¹, Kazuhiko Nakatani¹, Masateru Taniguchi¹ (1.Osaka Univ. SANKEN)

Keywords:Single-molecule measurement, MCBJ, Machine Learning

For the understanding of chemical reactions and the development of pharmaceuticals, methods to evaluate intermolecular interactions at the single molecule level are desirable. Single-molecule measurement is attracting attention as a method for evaluating intermolecular interactions. In this study, we aimed to develop a method to directly measure the affinity between molecules using single molecule measurement. Our developed method using of single-molecule measurement and Positive and Unlabeled data Classification (PUC), which is one of machine learning methods, reveals 72% of guanine-recognizing molecule aggregate with guanine. We have succeeded developing method to evaluate single-molecule interactions.