[IIIYS-02] Possible monoaminergic involvement in taurine induced hypothermia in chicks
Objective: Recently, we found that central injection of taurine induced hypothermia in neonatal chicks through GABAA receptor (Elhussiny et al., 2021). We further aimed to investigate the monoaminergic involvement in taurine induced hypothermia.
Materials and Methods: Five-days-old Julia chicks (n = 10) were centrally injected with saline or 5 μmol of taurine. Brain and plasma samples were collected for monoamine and free amino acid analyses.
Results: Central taurine significantly increased diencephalic tryptophan, the precursor of serotonin (5-HT), and 5-HT as well as its metabolite 5-hydroxyindoleacetic acid concentrations in chicks. Moreover, central taurine significantly decreased diencephalic tyrosine concentration, the precursor of catecholamines. However, the norepinephrine concentration in the brain stem and its metabolite 3-methoxy-4-hydroxyphenylglycol in both the brain stem and diencephalon were significantly increased following central injection of taurine.
Conclusion: These results indicate that serotoninergic and norepinephrinergic pathways may be involved in taurine induced hypothermia.
Materials and Methods: Five-days-old Julia chicks (n = 10) were centrally injected with saline or 5 μmol of taurine. Brain and plasma samples were collected for monoamine and free amino acid analyses.
Results: Central taurine significantly increased diencephalic tryptophan, the precursor of serotonin (5-HT), and 5-HT as well as its metabolite 5-hydroxyindoleacetic acid concentrations in chicks. Moreover, central taurine significantly decreased diencephalic tyrosine concentration, the precursor of catecholamines. However, the norepinephrine concentration in the brain stem and its metabolite 3-methoxy-4-hydroxyphenylglycol in both the brain stem and diencephalon were significantly increased following central injection of taurine.
Conclusion: These results indicate that serotoninergic and norepinephrinergic pathways may be involved in taurine induced hypothermia.