[ODP-103] Antimicrobial resistance of Neisseria gonorrhoeae isolated in Okinawa
Background: Gonorrhea is listed as one of the prioritized sexually transmitted infections (STIs) that requires global action for control. Neisseria gonorrhoeae (NG) has progressively developed resistance to many of previously effective antimicrobials. Because NG infections are not fully reportable in Japan, only limited data on disease epidemiology and antimicrobial susceptibility patterns are available. It is needed surveillance of NG antimicrobial susceptibility.
Methods: NG isolates in Okinawa prefecture were collected from April to October 2020, and identified by MALDI-TOF and HN-20 rapid Nissui, and tested for susceptibility to 5 drugs by standard agar dilution method according to Laboratory Standards Institute (CLSI) methods.
Results: Of the total isolates, intermediate or resistance susceptibility to penicillin G were most common, of which 40.0 % showed intermediate susceptibility and 50.0 % were resistant strains. Furthermore, high resistance was detected against tetracycline (63.6 %) and cefixime (50.0 %), whereas only 27.3 % of the strains showed resistance to azithromycin, and none to ceftriaxone.
Conclusions: Resistance or intermediate susceptibility to previously recommended antimicrobials, such as penicillin G, tetracycline and cefixime is common in the NG population. Ceftriaxone are recommended for first-line empiric antimicrobial monotherapy for NG in Okinawa.
Methods: NG isolates in Okinawa prefecture were collected from April to October 2020, and identified by MALDI-TOF and HN-20 rapid Nissui, and tested for susceptibility to 5 drugs by standard agar dilution method according to Laboratory Standards Institute (CLSI) methods.
Results: Of the total isolates, intermediate or resistance susceptibility to penicillin G were most common, of which 40.0 % showed intermediate susceptibility and 50.0 % were resistant strains. Furthermore, high resistance was detected against tetracycline (63.6 %) and cefixime (50.0 %), whereas only 27.3 % of the strains showed resistance to azithromycin, and none to ceftriaxone.
Conclusions: Resistance or intermediate susceptibility to previously recommended antimicrobials, such as penicillin G, tetracycline and cefixime is common in the NG population. Ceftriaxone are recommended for first-line empiric antimicrobial monotherapy for NG in Okinawa.